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  • 產(chǎn)品名稱(chēng):AIFM1抗原(重組蛋白)

  • 產(chǎn)品型號(hào):1mg
  • 產(chǎn)品廠商:通蔚生物
  • 產(chǎn)品價(jià)格:3580
  • 產(chǎn)品庫(kù)存:35
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詳情介紹:



中文名稱(chēng): AIFM1抗原(重組蛋白)

英文名稱(chēng): AIFM1 Antigen (Recombinant Protein)

儲(chǔ)     存:  冷凍(-20℃)

相關(guān)類(lèi)別: 抗原

概     述

Fusion protein corresponding to C terminal 250 amino acids of human AIFM1

技術(shù)規(guī)格

Full name:

apoptosis-inducing factor, mitochondrion-associated, 1

Synonyms:

AIF, PDCD8, COXPD6

Swissprot:

O95831

Gene Accession:

BC139738

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.







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