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  • 產(chǎn)品名稱：兔抗STAT1 (PhosphoTyr701)多克隆抗體

  • 產(chǎn)品型號：100ul
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：1800
  • 產(chǎn)品庫存：60
  • 產(chǎn)品文檔：
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隨著近幾年生物、生命科學(xué)的發(fā)展，抗體試劑的供應(yīng)商也越來越多，兔抗STAT1 (Phospho-Tyr701)多克隆抗體作為國內(nèi)生物試劑和消耗品的知名企業(yè)，上海通蔚生物有限公司不僅見證了行業(yè)的發(fā)展，也在發(fā)展的洪流中找準(zhǔn)了自己的位置，逆流而上，揚帆遠航。
詳情介紹：

中文名稱：  兔抗STAT1 (Phospho-Tyr701)多克隆抗體   

英文名稱： Anti-STAT1 (Phospho-Tyr701) rabbit polyclonal antibody

別      名： CANDF7; ISGF-3; STAT91

相關(guān)類別： 一抗

儲      存： 冷凍（-20℃） 避光

宿      主： Rabbit

抗      原： STAT1 (Phospho-Tyr701)

反應(yīng)種屬： Human Mouse

標(biāo) 記 物： Unconjugate

克隆類型： rabbit polyclonal

技術(shù)規(guī)格

Background:

Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.

Applications:

WB, IHC

Name of antibody:

STAT1 (Phospho-Tyr701)

Immunogen:

Synthetic peptide of human STAT1 (Phospho-Tyr701)

Full name:

signal transducer and activator of transcription 1, 91kDa (Phospho-Tyr701)

Synonyms：

CANDF7; ISGF-3; STAT91

SwissProt:

P42224

IHC positive control:

Human breast carcinoma

IHC Recommend dilution:

50-100

WB Predicted band size:

87 kDa

WB Positive control:

Hela cells treated with IFN

WB Recommended dilution:

500-1000





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