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  • 產(chǎn)品名稱(chēng)：VHL抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：1mg
  • 產(chǎn)品廠(chǎng)商：通蔚生物
  • 產(chǎn)品價(jià)格：3580
  • 產(chǎn)品庫(kù)存：35
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VHL抗原（重組蛋白）將進(jìn)一步加強(qiáng)人才培養(yǎng)、產(chǎn)品**，持續(xù)不斷地提升企業(yè)核心竟?fàn)幜?，?shí)現(xiàn)具有高科技產(chǎn)業(yè)體系、知識(shí)化創(chuàng)業(yè)團(tuán)隊(duì)的國(guó)際化企業(yè)，更好、更快捷、更全方位的服務(wù)于生命科學(xué)領(lǐng)域，迎接新一輪世界經(jīng)濟(jì)一體化所帶來(lái)的機(jī)遇與挑戰(zhàn)。
詳情介紹：

中文名稱(chēng)： VHL抗原（重組蛋白）

英文名稱(chēng)： VHL Antigen (Recombinant Protein)

別     名：  RCA1; VHL1; pVHL; HRCA1

儲(chǔ)     存：  冷凍（-20℃）

相關(guān)類(lèi)別： 抗原

概     述

Full length fusion protein

技術(shù)規(guī)格

Full name:

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Synonyms:

RCA1; VHL1; pVHL; HRCA1

Swissprot:

P40337

Gene Accession:

BC058831

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.





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