中文名稱: AIFM1抗原(重組蛋白)
儲 存: 冷凍(-20℃)
相關類別: 抗原
概 述
Full name: |
apoptosis-inducing factor, mitochondrion-associated, 1 |
Synonyms: |
AIF, PDCD8, COXPD6 |
Swissprot: |
O95831 |
Gene Accession: |
BC139738 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. |
