中文名稱(chēng): ALDH1A1/ALDH1A2/ALDH1A3抗原(重組蛋白)
英文名稱(chēng): ALDH1A1/ALDH1A2/ALDH1A3 Antigen (Recom Protein)
概 述
Full name: |
Aldehyde dehydrogenase 1 family, member A1/2/3 |
Synonyms: |
ALDC, ALDH1, PUMB1, ALDH11, RALDH1, ALDH-E1; RALDH2, RALDH2-T, RALDH(II); ALDH6, RALDH3, ALDH1A6 |
Swissprot: |
P00352/O94788/P47895 |
Gene Accession: |
BC001505/BC030589/BC069274 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. |
