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  • 產(chǎn)品名稱：CALR抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：3580
  • 產(chǎn)品庫(kù)存：35
  • 產(chǎn)品文檔：
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CALR抗原（重組蛋白）打造了一支訓(xùn)練有素的技術(shù)團(tuán)隊(duì)，為抗體產(chǎn)品質(zhì)量提供了強(qiáng)有力的保障，一直致力于研發(fā)生產(chǎn)高質(zhì)量的科研試劑，為生命科學(xué)提供**的蛋白檢測(cè)相關(guān)產(chǎn)品，先進(jìn)的實(shí)驗(yàn)設(shè)備，強(qiáng)大的技術(shù)力量，誠(chéng)信的服務(wù)態(tài)度是您實(shí)驗(yàn)成果的保障！
詳情介紹：


中文名稱： CALR抗原（重組蛋白）

英文名稱： CALR Antigen (Recombinant Protein)

儲(chǔ)     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Fusion protein corresponding to a region derived from 20-218 amino acids of human CALR

技術(shù)規(guī)格

Full name:

Calreticulin

Synonyms:

RO; CRT; SSA; cC1qR

Swissprot:

P27797

Gene Accession:

BC002500

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.





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