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  • 產(chǎn)品名稱：DFFA抗原（重組蛋白）

  • 產(chǎn)品型號：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：3580
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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詳情介紹：


中文名稱： DFFA抗原（重組蛋白）

英文名稱： DFFA Antigen (Recombinant Protein)

別     名：  DFF1; ICAD; DFF-45

儲     存：  冷凍（-20℃）

相關類別： 抗原

概     述

Fusion protein corresponding to N terminal 269 amino acids of human DFFA

技術規(guī)格

Full name:

DNA fragmentation factor, 45kDa, alpha polypeptide

Synonyms:

DFF1; ICAD; DFF-45

Swissprot:

O00273

Gene Accession:

BC007721

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.





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