別 名: glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); II; CCAT; IGNT; ULG3; GCNT5; GCNT2C; NACGT1; NAGCT1; CTRC
概 述
Full name: |
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) |
Synonyms: |
II; CCAT; IGNT; ULG3; GCNT5; GCNT2C; NACGT1; NAGCT1; CTRCT13; bA421M1.1; bA360O19.2 |
Swissprot: |
Q8N0V5 |
Gene Accession: |
BC130524 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to ***** I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with ***** i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. |
