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  • 產(chǎn)品名稱：IFIT3 抗原（重組蛋白）

  • 產(chǎn)品型號：100ug
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價格：800
  • 產(chǎn)品庫存：35
  • 產(chǎn)品文檔：
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IFIT3 抗原（重組蛋白）一直視質(zhì)量控制為企業(yè)的生命，追求企業(yè)競爭力的不斷提升，始終秉承信譽為生存之本的宗旨，以過硬的質(zhì)量和優(yōu)良的服務來維護和拓展市場，*大限度的滿足客戶的需求，與客戶共贏，是我們的發(fā)展目標，愿與您精誠合作，共創(chuàng)美好的未來。
詳情介紹：


中文名稱： IFIT3 抗原（重組蛋白）

英文名稱： IFIT3 Antigen (Recombinant Protein)

別     名：  interferon induced protein with tetratricopeptide repeats 3; P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49

儲     存：  冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Fusion protein corresponding to a region derived from 291-490 amino acids of human IFIT3

技術(shù)規(guī)格

Full name:

interferon induced protein with tetratricopeptide repeats 3

Synonyms:

P60; IRG2; IFI60; IFIT4; ISG60; RIG-G; cig41; CIG-49; GARG-49

Swissprot:

O14879

Gene Accession:

BC001383

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.





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