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  • 產(chǎn)品名稱：IL6ST 抗原（重組蛋白）

  • 產(chǎn)品型號(hào)：1mg
  • 產(chǎn)品廠商：通蔚生物
  • 產(chǎn)品價(jià)格：3580
  • 產(chǎn)品庫(kù)存：35
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中文名稱： IL6ST 抗原（重組蛋白）

英文名稱： IL6ST Antigen (Recombinant Protein)

別     名： interleukin 6 signal transducer; CD130; GP130; CDW130; IL-6RB

儲(chǔ)     存： 冷凍（-20℃） 

相關(guān)類別： 抗原

概     述

Fusion protein corresponding to a region derived from 670-918 amino acids of human IL6ST

技術(shù)規(guī)格

Full name:

interleukin 6 signal transducer

Synonyms:

CD130; GP130; CDW130; IL-6RB

Swissprot:

P40189

Gene Accession:

BC117402

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.







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